隐匿性乙型肝炎病毒感染的发生机制和检测

The mechanism and detection of occult hepatitis B infection

对隐匿性乙型肝炎病毒(乙肝病毒)感染的发生机制和检测方法进行综述,显示:乙肝病毒复制水平较低、病毒变异导致现有乙肝病毒表面抗原(HBsAg)试剂难以检出以及外周血单核细乙肝病毒感染是隐匿性乙肝病毒感染发生的重要原因,宿主因素以及丙肝病毒感染、血吸虫感染和长期饮酒等也与其发生有关。目前隐匿性乙肝病毒感染的检测方法和判断标准尚不一致。急需统一隐匿性乙肝病毒感染的检测方法和判断标准,并对其发生的分子机制及不同分子模式的发生频率开展进一步研究。

Low levels of hepatitis B virus （HBV） DNA, viral mutation leading to failure of hepatitis B surface antigen （HBsAg） detection and peripheral blood monouclear cells （PMBC） infected by HBV are the main reasons for occult hepatitis B virus infection（OBI）. The host＇s immune state and HCV infection, schistosoma infection and long-time drinking also play parts in OBI. Until now, there were no uniform way to detect OBI and the standards to judge detection results varied in different studies. Formulating the uniform standards to detect OBI is very necessary to compare the different studies. And further studies were also needed to classify the molecular form about OBI and their relative frequency.