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泮托拉唑钠的合成 被引量：2

Synthesis of Pantoprazole Sodium
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摘要 以2-氯甲基-3,4-二甲氧基吡啶盐酸盐和5-二氟甲氧基-2-巯基-1H-苯并咪唑为原料,用二氯甲烷和水作溶剂,经相转移催化缩合反应、用次氨酸钠氧化、成盐反应三步"一锅法"制得泮托拉唑钠,总收率约75%。 Pantoprazole Sodium was prepared from 2-chloromethyl-3,4-dimethoxypyridine hydrochloride and 5-difluoromethoxy-2-mercapto-lH-benzimidazole in dichloromethane and water by condensation under phase transfer catalysis, oxidation with sodium hyphchlorite and salt formation with an overall yield of about 75 %.
作者 宋伟国 张福建 方浩
机构地区 寿光富康制药有限公司 山东大学药学院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2008年第12期891-893,共3页 Chinese Journal of Pharmaceuticals
关键词 泮托拉唑钠 抗溃疡药 相转移催化剂 合成 pantoprazole sodium antiulcer drug phase transfer catalyst synthesis
分类号 R975.6 [医药卫生—药品]
  • 相关文献

参考文献8

  • 1毛煜,佘佳红,袁伯俊.苯并咪唑类质子泵抑制剂的药理和临床研究进展[J].中国新药杂志,2006,15(1):17-21. 被引量：28
  • 2魏云,唐映红,吉兰,孟庆玉.泮托拉唑钠抗胃溃疡药理研究[J].中国医药工业杂志,2000,31(3):116-118. 被引量：8
  • 3王庆河,程卯生,黄国宾,潘莉,沈建民.泮托拉唑钠的合成研究[J].中国药学杂志,1999,34(8):564-565. 被引量：8
  • 4Kohl B, Sturm E, Serm-Bilfinger J, et al. (H^+,K^+) -ATPase inhibiting 2- [ (2-pyridylmethyl) sulfinyl] benzimidazoles, 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate [J]. JMed Chem, 1992, 35(6): 1049-1057.
  • 5Mathad VT, Govindan S, Kolla NK, et al. An improved and single-pot process for the production of pantoprazole substantially free from sulfone impurity [J]. Org Proc Res Dev, 2004, 8 (2) : 266-270.
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二级参考文献26

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共引文献39

同被引文献9

  • 1毛煜,佘佳红,袁伯俊.苯并咪唑类质子泵抑制剂的药理和临床研究进展[J].中国新药杂志,2006,15(1):17-21. 被引量：28
  • 2Schul HU, Hartmann M, Steinijans VW, et al. Lack of influence of pantoprazole on the disposition kinetics of theophylline in man [J]. Int J Clin Pharmacol Ther, 1996, 34 (1 suppl) : S51-S57.
  • 3Kohl B, Sturm E, Senn-Bilfinger J, et al. (H+,K+) -ATPase inhibiting 2- [ (2-pyridylmethyl) sulfinyl] benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate [J].J Med Chem, 1992, 35(6): 1049-1057.
  • 4Brennan JP, Turner AT. Chemical process for the production of sulphinyl derivatives by oxidation of the correspondiny co-derivatives with perborates: WO, 9947514 [P]. 1999-09-23. (CA 1999, 131: 228722)
  • 5Kohl Bernhard,Senn-Bilfinger Joerg. Separation of enan-tiomers[P].WO 1992008716,1992.
  • 6Larsson EM,Stenhehe UJ,Sorensen H. Process for synthesisof substituted sulphoxides[P].US 5948789A,1999.
  • 7Mathad VT,Govindan S,Kolla NK. An improved and single-pot process for the production of pantoprazole substantially flee from sulfone impurity[J].Org Proc Res Dev,2004,(02):266-270.
  • 8周春晖,谢华丽,杜泽学,范永仙,葛忠华,李小年.钼、钨类水滑石材料的合成、结构及催化环氧化性能[J].高校化学工程学报,2009,23(3):516-521. 被引量：5
  • 9魏云,唐映红,吉兰,孟庆玉.泮托拉唑钠抗胃溃疡药理研究[J].中国医药工业杂志,2000,31(3):116-118. 被引量：8

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中国医药工业杂志
2008年 第12期

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