摘要
以2-氯甲基-3,4-二甲氧基吡啶盐酸盐和5-二氟甲氧基-2-巯基-1H-苯并咪唑为原料,用二氯甲烷和水作溶剂,经相转移催化缩合反应、用次氨酸钠氧化、成盐反应三步"一锅法"制得泮托拉唑钠,总收率约75%。
Pantoprazole Sodium was prepared from 2-chloromethyl-3,4-dimethoxypyridine hydrochloride and 5-difluoromethoxy-2-mercapto-lH-benzimidazole in dichloromethane and water by condensation under phase transfer catalysis, oxidation with sodium hyphchlorite and salt formation with an overall yield of about 75 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2008年第12期891-893,共3页
Chinese Journal of Pharmaceuticals
关键词
泮托拉唑钠
抗溃疡药
相转移催化剂
合成
pantoprazole sodium
antiulcer drug
phase transfer catalyst
synthesis