咽喉炎合剂中黄芩苷的稳定性考察

Stability of the Baicalin in Yanhouyan Mixture

目的:考察咽喉炎合剂的稳定性。方法:采用经典恒温加速试验法和留样观察法,以黄芩苷的含量作为考察指标,采用高效液相色谱(HPLC)法测定其含量的变化。结果:咽喉炎合剂中黄芩苷的含量变化符合一级动力学过程,2种考察方法的结果基本一致。在室温(25℃)条件下,咽喉炎合剂的有效期为1.06a。结论:建议咽喉炎合剂质量标准中有效期订为室温保存1a。

OBJECTIVE：To investigate the stability of Yanhouyan mixture（for pharyngolaryngitis）.METHODS： The stability of Yanhouyan mixture was investigated by classic constant temperature accelerated test method and sample observation method taking the content of Baicalin as index which was determined by HPLC.RESULTS： The content change of Bacilin in Yanghouyan mixture was in line with the first order kinetics, and the test results for both methods were similar.Under room temperature（25 ℃ ）, the validity duration of Yanhouyan mixture was 1.06 years.CONCLUSION： In establishing the quality standard for Yanhouyan mixture, the advisable storage life of 1 year for which should be considered .