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高血压病主动脉夹层与基质金属蛋白酶-9的关系研究进展 被引量：5

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摘要 基质金属蛋白酶(MMPs)参与并促进主动脉中层基质胶原蛋白和弹性蛋白的分裂、降解及血管再塑形,高血压病发生主动脉夹层时间质细胞的活性增加使MMPs-9大量增加并进入血循环,导致动脉血管重构、弹性减退及损伤,促进主动脉夹层的形成。
作者 刘亚欣 樊晓寒 惠汝太
机构地区 中国协和医科大学 北京阜外心血管病医院
出处 《中国分子心脏病学杂志》 CAS 2008年第6期380-382,共3页 Molecular Cardiology of China
关键词 基质金属蛋白酶-9 高血压病 主动脉夹层
分类号 R544.1 [医药卫生—心血管疾病] R543.1 [医药卫生—心血管疾病]
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参考文献13

  • 1陈燕,陈慧.基质金属蛋白酶-9与易损斑块[J].心血管康复医学杂志,2007,16(1):96-98. 被引量：15
  • 2朱少华,张慧,朱金龙,蒋艳伟,郑娜,刘良.主动脉夹层破裂与非破裂管壁的病理学对比观察[J].中国法医学杂志,2006,21(2):79-81. 被引量：10
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  • 4[4]Defawe OD,Kenngy RD.Choi C,et al.MMP-9 regulates both posi-tively and negatively collagen gel contraction:a nonproteolytic func-tion of MMP-9[J].cardlovasc Res,2005,66(2):402-409.
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  • 9宋卫华,党爱民,朱俊明,吕纳强,刘国仗,惠汝太.高血压合并主动脉夹层基质金属蛋白酶9基因-1562C/T多态性[J].中华内科杂志,2006,45(5):376-378. 被引量：8
  • 10[10]Ishii T,Asuwa N.Collagen and elastm degradation by matrix metal-lopmteinases and hssue mhibltors of marx metalloproteinase in aortic dissection.Hum Pathol,2000.31:640-646.

二级参考文献28

  • 1张慧,朱少华,秦启生,宋旭东,史为栋.小鼠皮肤创伤愈合过程中IL-10在不同表达部位的组化定量研究[J].法医学杂志,2004,20(2):70-72. 被引量：1
  • 2Growther M,Goodall J,Jones LJ,et al.Localization of matrix metalloproteinase within the aneurysmal and normal aortic wall[J].BrJ Surg,2000,87(3):1391 -1400.
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  • 4John AC,Shixiong L,Mark D,et al.Expression and localization of macrophage elastase (matrix metalloproteinase-12)in abdominal aortic aneurysms[J].J Clin Invest,1998,102(11):1900-1910.
  • 5Jones GT, Phillips VL, Harris EL, et al. Functional matrix metalloproteinase-9 polymorphism (C-1562T) associated with abdominal aortic aneurysm. J Vasc Surg, 2003,38:1363-1367.
  • 6Nienaber CA, Eagle KA. Aortic dissection : new frontiers in diagnosis and management: Part Ⅱ: therapeutic management and follow-up.Circulation ,2003,108:772-778.
  • 7Kadoglou NP, Liapis CD. Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms. Curr Med Res Opin, 2004,20:419-432.
  • 8Ishii T, Asuwa N. Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection. Hum Pathol, 2000,31:640-646.
  • 9Manabe T, Imoto K, Uchida K, et al. Decreased tissue inhibitor of metalloproteinase-2/matrix metalloproteinase ratio in the acute phase of aortic dissection. Surg Today ,2004,34:220-225.
  • 10Zhang B, Ye S, Herrmann SM, et al. Functional polymorphism in the regulatory region of gelatinase B gene in relation to severity of coronary atherosclerosis. Circulation, 1999,99 : 1788-1794.

共引文献29

同被引文献83

引证文献5

二级引证文献39

中国分子心脏病学杂志
2008年 第6期

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