乳腺癌术前空心针穿刺活检与手术切除标本的免疫组化比较研究

A comparative study of immunohistochemistry on prcoperative core needle biopsy and Surgical excision specimens for breast caneer

目的评估空心针穿刺活检的标本是否可以准确反映术前化疗的乳腺癌患者手术后的病理组织学状态。方法收集我科于2006年12月～2007年12月35例乳腺癌在术前接受化疗的临床资料。对其中25例的术前空心针穿刺标本(CB)和手术后标本(SS)的雌激素受体(ER)、孕激素受体(PR)、HER2基因表达、Ki67和P53的免疫组织化学检查结果进行比较分析。结果术前空心针穿刺活检与手术切除标本ER和PR的不一致率分别为22.7%和13.6%;HER2的不一致率为22.7%;Ki67和P53的不一致率为30%。结论空心针穿刺标本与手术切除标本的免疫组化状态有一定的不致性。因此,在选择治疗方案时应进行综合考虑状态。

Objective To investigate the immunohistochemical difference between preoperative core needle biopsy and surgical excision specimens for breast cancer. Methods From December 2006 to December 2007, the clinical daa of 35 cases received preoperaive chemotherapy were collected. Among them, in the immunohistochemical results of the ER, PR, HER-2 gene, Ki 67 and P53,25 cases of preoperative core needle biopsy and surgical excision specimens were compared. Results In the preoperative core needle biopsy and surgical excision specimens, dis-cordanee rates of ER and PR were in 22.7% and 13.6% respectively,discordance rate of HER-2 was in 22.7% and discordance rates of Ki 67 and P53 were in 30%. Conclusion Core needle biopsy and surgical excision specimens have a definate discordance. Therefore, a comprehensive consideration should be taken during choice of therapeutic project.