Antiphospholipid Antibody and Antiphospholipid Syndrome

Antiphospholipid antibodies(APA)APA is a big category for all kinds of negative charge phospholipid or lecithin- a protein complex autoantibodies or the same antibody,through its recognition of antigen(target protein) different,and

Antiphospholipid antibodies （APA） APA is a big category for all kinds of negative charge phospholipid or lecithin - a protein complex autoantibodies or the same antibody, through its recognition of antigen （ target protein） different, and phospholipids or lecithin - protein complex combination of various rely on the interference Phospholipid clotting and anti-coagu- lation factor, and promote endothelial cells, platelets, complement activation and play a role. APA including lupus anticoagulant （ LA ） and anticardiolipin antibody （ACA）, In addition, there are anti-β2 glycoprotein-I （β2-GPI） antibody, anti- prothrombin （ a- PT） antibody, anti-lysophosphatidic acid antibody and anti-phosphatidylserine antibody, and so on. APA as the main target of phospholipid-binding protein, including β2-GPI, prothrombin, annexin, protein C （PC） and protein S （PS） , plasminogen, and so on.