丙戊酸钠对癫痫患儿尿pH值及结晶体的影响

Effect of sodium valproate on urinary pH and crystalluria in children with epilepsy

目的:了解丙戊酸钠对癫痫患儿尿pH值及结晶体的影响。方法:44例癫痫患儿(男24例,女20例)年龄2～11岁,给予丙戊酸钠单药治疗后,观察其尿pH值及结晶体变化情况,并与40例对照组进行比较。结果:癫痫组患儿服用丙戊酸钠后碱性尿出现比例较对照组增高(P<0.05),晶体尿出现比例差异不明显(P>0.05)。结论:丙戊酸钠可致癫痫患儿尿pH值升高。

Objective： To explore the effect of sodium valproate on urinary pH and crystaUuria in children with epilepsy. Methods： forty -four children （24 boys and 20 girls） aged from 2 to 11 years with epilepsy participated in the study. They had the history of epilepsy between two and twelve months. There were 40 children served as controls. Sodium valproate was used as monotherapy. Urinary pH was examined using a test paper. Crystalluria was inspected by microscope. Results： The proportion of the alkaline urine in the valproate - treated patients was higher than that in controls （ P 〈 0. 05 ） . There was no significant difference in the frequency of crystalluria between children treated with sodium valproate and the controls （P 〉 0. 05） . Conclusions： Sodium valproate could raise urinary pH in children with epilepsy.