趋化因子受体CCR7在肺癌及转移淋巴结中的表达及其意义

Expression and Clinical Significance of Chemokine Receptor CCR7 in Lung Cancer Tissues and Corresponding Metastasized Lymph Nodes

目的探讨肺癌原发灶及淋巴结转移灶中趋化因子受体CCR7的表达特点及其与临床病理特征的关系。方法对125例肺癌手术切除标本及64例淋巴结转移灶和20例癌旁正常肺组织采用免疫组化法检测CCR7表达。结果CCR7在57.6%(72/125)肺癌组织中呈阳性表达,20例癌旁正常组织中仅2例表达(10.0%)。64例肺癌原发灶和淋巴结转移灶中CCR7高表达的阳性率分别为82.8%(53/64)和81.2%(52/64),两部位CCR7表达具有较高的同源性。CCR7的表达与肺癌患者的性别、年龄、肿瘤大小、肿瘤分化程度和组织学类型无关(P>0.05),而与肺癌患者的临床分期及有无淋巴结转移密切相关(P<0.01)。结论CCR7表达与肺癌淋巴结转移密切相关,CCR7在肺癌原发灶及转移淋巴结中的表达具有较高的同源性。CCR7的表达对指导手术方式的选择及非手术治疗选择靶点具有指导价值。

Objective To investigate the expression features of CC chemokine receptor 7 （CCR7） in human lung cancer tissues and corresponding metastasized lymph nodes, as well as their relation with clinicopathologic features. Methods The expression of CCR7 was tested by immunohistochemical method in 125 lung carcinoma specimens, 64 corresponding metastasized lymph nodes and 20 pericancerous normal lung specimens. Results C12R7 expression was positive in 57. 6% （72/125） of lung carcinoma specimens, in only 2 normal lung specimens of 20. High expression rate of CCR7 in 64 primary lung lesions and corresponding metastasized lymph nodes was 82. 8% （53/64） and 81.2% （52/64） respectively. Furthermore, homogenesous expression of CCR7 was found in the prinmry lung lesions and metastasized lymph nodes. Expression of CCR7 was relevant to lymph node metastasis and clinical stage of the lesions （P〈0. 01）, but not to age, gender, tumor size, differentiation degree of tumor or histologic type （P〉0. 05）. Conclusion The expression of CCR7 is closely correlated to lymph node metastasis of lung cancer and clinical stages. In most of metastasis-positive cases, homogeneous expression of CCR7 is found between primary lung cancer and metastasized lymph nodes. Evaluation of CCR7 expression has some guidance values in selection of surgical manner and selection of targets of nonsurgical therapy.