急性脑梗死患者血浆血栓素B2、6-酮-前列腺素F1α及其比值水平的动态变化与临床意义

Dynamic Analysis for Level of Plasma TXB_2,6-keto-PGF_(1α) and TXB_2/6-keto-PGF_(1α) of Patients with Acute Cerebral Infarction and Its Clinic Significance

目的通过测定急性脑血管病患者血浆血栓素B2(TXB2),6-酮-前列腺素F1α(6-keto-PGF1α)的含量及其动态变化,了解血小板功能变化。方法检测205例急性脑梗死患者发病后24 h内、1周时、2周时的血浆TXB2和6-keto-PGF1α含量及其比值(T/6-K),并与正常对照组(n=40)进行比较。结果急性脑梗死患者发病后24 h内、1周时、2周时的血浆TXB2和6-keto-PGF1α的含量均明显高于正常正对照组(P<0.01);TXB2在1周时达峰值,至2周时下降;6-keto-PGF1α逐渐增高,至2周时达峰值;T/6-K在发病后24 h内、1周时均明显高于正常正对照组(P<0.01),1周时达峰值,至2周时下降,基本与正常对照组相似(P>0.05)。结论TXB2、6-keto-PGF1α及T/6-K的测定有助于了解急性脑梗死患者血小板功能的变化,保持TXB2与6-keto-PGF1α的平衡对维持血流通畅有重要意义。

Objective To assess the level of plasma thromboxane B2 （TXB2）, 6-keto prostaglandin F1α （6 keto-PGF1α ） of patients with acute cerebral infarction, so as to know the changes of platelet function on acute cerebral vascular diseases. Methods The level of plasma TXB2, 6-keto PGF1α and TXB2/6 keto-PGF1α （T/6 K） of 205 patients with acute cerebral infarction were measured within 24 hours and on the 7th day and 14th day, and were compared with the normal controls （n 40）. Results The levels of plasma TXB2, 6- keto-PGF1α of patients within 24 hours, on the 7th day and 14th day were significantly higher than those in the normal controls （P 〈0.01）. The level of plasma TXB2 was the highest on the 7th day and decreased on 14th day. The level of plasma 6 keto PGF1α was the highest on the 14th day. T/6 K was higher than those in the normal controls within 24 hours and on the 7th day; it was highest on the 7th day and decreased on 14th day to level of the normal controls （ P 〉0.05）. Conclusion The determine on levels of plasma TXB2, 6-keto-PGF1α, has important significance for knowing the changes of platelet function on acute cerebral infarction. The balance between TXB2 and 6 keto-PGF1α is important in keeping the blood smoothly.