手性药物的酶催化不对称定向合成

Asymmetric Oriented Synthesis of Chiral Drugs Catalyzed by Enzyme

手性药物目前已成为国际上新药研究的热点。手性药物及其中间体的酶催化定向合成与传统的有机合成反应相比，所需条件温和，无需强酸强碱、高温高压等极端条件，可大大降低对设备的要求，同时具备反应速度快、立体选择性高等优势，而且对环境污染小，属于绿色合成技术，因而成为制备手性化合物的最有前景的方法之一。本文主要介绍了手性药物的酶催化不对称定向合成的方式、催化机理及应用，并引入了一些最新进展情况。

Chiral drug has been a hot topic of new drug research in the world. The asymmetric oriented synthesis of chiral drug and its intermediate catalyzed by enzyme has many advantages compared with the traditional organic synthesis, such as moderate conditions, no strong acid and alkali as well as high pressure and temperature needed, not strict demand on equipments, faster reaction rate, high stereoselectivity and small environmental pollution, so it belongs to green synthesis technology and has become a most promising preparation method of chiral compound. This paper introduces the way, catalytic mechanism and application of asymmetric oriented synthesis of chiral drugs catalyzed by enzyme,and some of the latest developments.