老年性痴呆患者血清脂质、脂蛋白、载脂蛋白水平变化的研究

A study on change of lipid metabolism in senile dementia

目的探讨脂代谢异常在老年性痴呆病因中的作用。方法选取46例老年性痴呆患者及50例正常对照者，抽取其静脉空腹血，运用单克隆抗体-免疫酶联吸附法（McAb—ELISA）测定其血清载脂蛋白E（ApoE）含量，同时测定血清中总胆固醇（TC）、甘油三脂（TG）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）、极低密度脂蛋白（VLDL—C）、载脂蛋白B（ApoB）和载脂蛋白A（ApoA）含量，并对结果进行比较。结果①老年性痴呆组ApoB[（1．72±0．65）mg／L]的水平较对照组[（1．21±0．54）mg／L]明显升高，组间比较差异有显著性（P〈0．05）；②与对照组[TC、TG、LDL—C、ApoA、ApoE分别为（5．64±2．14）mmol/L、（1．51±1．23）mmol/L、（4．08±0．74）mmol/L、（1．76±0．55mg／L）、（5，21±1．32）mg／L]比较，老年性痴呆组TC[（5．86±2．31）mmol／L]、TG[（1．65±1．21）mmol/L]、LDL—C[（4．10±0．65）mmol/L]、ApoA[（1．85±0．65）mg／L]、ApoE[（5．32±1．45）mg／L]水平较高，但2组间比较差异无显著性（P〉0．05）；③与对照组比较，老年性痴呆组HDL—C、VLDL—C水平则较低，但2组间比较差异无显著性（P〉0．05）。结论脂代谢紊乱在老年性痴呆病因中可能发挥重要作用。

Objective To explore the effect of change of lipid metabolism on senile dementia onset. Methods Serum TC,TG,HDL-C,LDL-C, VLDL-C, ApoA, ApoB, ApoE levels were measured in 76 cases of senile dementia （Senile dementia group,SD）and 100 sex and age matched control subjects（ Control group,CG） ,and compared results between SD and CG. Results Compared with CG, the levels of TC, TG, LDL-C, ApoA, ApoE were higher, and the the levels of HDL-C, VLDL-C were lower in SD, but there was no distinctly difference between SD and CG（P 〉 0.05 ）. The levels of ApoB in SD were higher than that of CG, and there was distinctly difference between SD and CG（P 〈0. 05 ）. Conclusion The change of lipid metabolism probably play an important role in senile dementia onset.