磁性载药微球应用于热化疗的研究进展

Research advances in thermochemotherapy of drug-loaded magnetic micro/nano-particles

将磁性载药微球用于恶性肿瘤热化疗是一种肿瘤治疗的新策略，其优势表现在兼具化疗和热疗（特别是细胞内热疗）的高度靶向性和特异性等多方面。磁性载药微球多由铁氧化物和水溶性的抗肿瘤药物组成，利用磁性载药微球在交变磁场下发热的特点进行热疗和化疗的协同治疗，可使肿瘤体积减小甚至消失。

Thermochemotherapy by drug-loaded magnetic micro/nano-particles is attracting increasing attention because it combines the advantages of chemotherapy and high targeting and selectivity of hyperthermia, especially intra-cellular hyperthermia. Magnetic miero/nano-partieles, usually consisting of biodegradable poly- mers matrics co-incorporated with ferromagnetic particles and anti-cancer drugs, will generate heat when exposed to an externally applied alternating magnetic fields due to electromagnetic induction by ferro-particles, in the meanwhile, sensitivity of anti-cancer drug will be greatly enhanced by higher temperature. Tumors will greatly suppressed by the synergetie effect of chemotherapy and targeted hyperthermia.