胰腺移植免疫耐受研究进展

Current Research Advancement of Immune Tolerance in Pancreas Transplantation

目的总结胰腺移植免疫耐受的研究进展。方法分析近年来有关胰腺移植免疫耐受研究进展的文献报道。结果外周性耐受及中枢性耐受是诱导免疫耐受的主要方法,其中通过供体特异性骨髓细胞输注诱导嵌合体形成是目前的研究热点。结论供体特异性骨髓细胞输注联合一种或多种外周性耐受方法有望诱导胰腺移植免疫耐受,但需进行深入研究。

Objective To summarize the advancement of immune tolerance in pancreas transplantation. Methods Relevant literatures about immune tolerance in pancreas transplantation, which were published recently domestic and abroad were collected and reviewed. Results The main methods to induce immune tolerance are peripheral tolerance and central tolerance. The induction of chimerism by infusion of donor-specific bone marrow cells is the research hot spot recently. Conclusion The infusion of donor-specific bone marrow cells in combination with one or more peripheral tolerance maybe can induce immune tolerance successfully. However, it should be researched further.