单核苷酸多态性与乳腺癌化疗应答

Single Nucleotide Polymorphism and Chemotherapy Response of Breast Cancer

目的探讨单核苷酸多态性(SNP)与乳腺癌常规化疗药物治疗应答间的相关性及其在指导个体化治疗中的价值。方法检索Pub-Medline和中国CHKD期刊数据库,对近年来此领域有代表性的文献进行整理、归纳。结果多种药物代谢相关基因存在SNP现象,且与药物效应个体多样性有着密切联系。人种、地域、环境、基因间或药物间相互作用可能会对这种关系产生影响。结论SNP研究对于优化个体用药具有重要的应用前景,但多基因多SNP组合分析以及大样本、前瞻性随机对照研究还非常必要。

Objective To investigate the relationship between single nueleotide polymorphism （SNP） and therapy response of some conventional chemotherapy drugs in breast cancer, and to explore the value of SNP in guiding individualized treatment. Methods Pub-Medline and Chinese CHKD periodical electronic databases were searched. Representative researches in this field were sorted out and concluded. Results Varied genes related to drug metabolism have SNP phenomenon, which are closely associated with interindividual diversity in drug response. Race, section, environment, and drug-drug or gene-gene interactions may have effect on the association. Conclusion The study on SNP has important application prospect in optimizing the individual drug-delivery. However, the combinatorial analyses of rnulti-SNPs and multi genes and the prospective studies with large scale samples and random controls are still needed,