期刊文献+

帕金森病发病机制的研究现状 被引量:1

Pathogenetic study of parkinson's disease
下载PDF
导出
摘要 帕金森病(parkinson disease,PD)是中枢神经系统常见的一种变性疾病,中老年发病,起病缓慢,慢性进行性发展,以静止性震颤、肌强直、姿势异常和运动减少为主要表现。主要病变在黑质致密带,可累及蓝斑、迷走神经背核等。尽管病理改变位置明确、局限,但帕金森病的病因及发病机制目前仍不明确,本文就PD发病机制的进展作一综述。
出处 《局解手术学杂志》 2008年第6期420-421,423,共3页 Journal of Regional Anatomy and Operative Surgery
  • 相关文献

参考文献3

二级参考文献28

  • 1Leroy E, Boyer R, Auburger G, et al. The ubiquitin pathway in Parkinson' s disease. Nature, 1998,395:451-452.
  • 2The extrapyramidal disease conference in China. Diagnostic criteria and differential diagnosis of Parkinson' disease and Parkinson' s syndrome. Chin J Neuro, 1985,18:256.
  • 3Dawson TM, Dawson VL. Molecular pathways of neurodegeneration in Parkinson' s disease. Science, 2003,302: 819-822.
  • 4Osaka H, Wang YL,Takada K, et al. Ubiquitin carboxy-tenninal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet ,2003, 12 : 1945-1958.
  • 5Maraganore DM,Farrer MJ,Hardy JA, et al. Case-control study of the ubiquitin carboxy-tenninal hydrolase L1 gene in Parkinson's disease. Neurology, 1999,53 : 1858-1860.
  • 6Wintermeyer P, Kruger R, Kuhn W, et al. Mutation analysis and association studies of the UCHL1 gene in German Parkinson' s disease patients. Neuroreport , 2000,11:2079-2082.
  • 7Momose Y,Murata M, Kobayashi K, et al. Association studies of multiple candidate genes for Parkinson' s disease using single nucleotide polymorphism. Ann Neurol,2002,51 : 133-136.
  • 8Tan EK, Puong KY, Fook-Chong S, et al. Case-control study of UCHL1 S18Y variant in Parkinson's disease. Mov Disord,2006,21 : 1765-1768.
  • 9Healy DG, Abou-Sleiman PM, Wood NW. Genetic causes of Parkinson' s disease: UCHL-1. Cell Tissue Res ,2004,318:189-194.
  • 10Nishikawa K, Li H, Kawamura R, et al. Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-tenninal hydrolase L1 variants. Biochem Biophys Res Commun , 2003,304: 176-183.

共引文献9

同被引文献6

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部