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干扰素γ与肝纤维化治疗 被引量：2

Interferon gamma and the treatment of hepatic fibrosis
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摘要 干扰素γ（IFNγ）具有很强的抗肝纤维化作用，近年来IFNγ治疗肝纤维化的临床和基础研究已有很大进展，现就此作一综述。
作者 翁红雷 蔡卫民
机构地区 Molecular Alcohol Research in gastroenterology 浙江大学医学院附属第一医院传染病研究所、传染病诊治国家重点实验室
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2008年第12期955-957,共3页 Chinese Journal of Hepatology
关键词 干扰素Γ 肝纤维化 治疗 Interferon-gamma Liver fibrosis Treatment
分类号 R575.2 [医药卫生—消化系统] R512.6 [医药卫生—内科学]
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参考文献15

  • 1Weng HL, Wang BE, Jia JD, et al. Effect of interferon-gamma on hepatic fibrosis in chronic hepatitis B virus infection: a randomized controlled study. Clin Gastroenterol Hepatol, 2005, 3: 819-828.
  • 2Muir AJ, Sylvestre PB, Rockey DC. Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection. J Viral Hepat, 2006, 13: 322-328.
  • 3Pockros P J, Jeffers L, Afdhal N, et al. Final results of a doubleblind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis. Hepatology, 2007, 45: 569-578.
  • 4Soza A, Heller T, Ghany M, et al. Pilot study of interferon gamma for chronic hepatitis C. J Hepatol, 2005, 43:67-71.
  • 5Bedossa P, Dargere D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology, 2003, 38: 1449-1457.
  • 6Chevillard C, Moukoko CE, Elwali NE, et al. IFN-gamma polymorphi sms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni). J Immunol, 2003, 171: 5596-5601.
  • 7Booth M, Mwatha JK, Joseph S, et al. Pefiportal fibrosis in human Sehistosoma mansoni infection is associated with low IL-10, low IFN-gamma, high TNF-alpha, or low RANTES, depending on age and gender. J Irnmunol, 2004, 172: 1295-1303.
  • 8Dessein A, Kouriba B, Eboumbou C, et al. Interleukin-13 in the skin and interferon-gamma in the liver are key players in immune protection in human schistosomiasis. Immunol Rev, 2004, 201: 180- 190.
  • 9Dessein AJ, Hillaire D, Elwali NE, et al. Severe hepatic fibrosis in Schistosoma mansoni infection is controlled by a major locus that is closely linked to the interferon-gamma receptor gene. Am J Hum Genet, 1999, 65: 709-721.
  • 10Jeong Wl, Park O, Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology, 2008, 134: 248-258.

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中华肝脏病杂志
2008年 第12期

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