山羊自体骨软骨移植的3.0T磁共振成像

3.0T MRI of autologous osteochondral transplantation in a goat model

目的探讨自体骨、软骨移植术修复软骨缺损的MRI表现特点。方法10只健康成年山羊随机分为5组。在股骨内侧髁负重面制造一圆柱形骨软骨缺损,自非负重面取3个骨软骨柱以马赛克方式填入缺损区。采用Philips Achieva 3.0T磁共振扫描仪。结果移植物信号与正常骨软骨一致,修复组织早期表现为高信号,随时间进展逐渐变为偏低信号。组织学显示移植物基本保持原有结构,修复组织为纤维软骨或纤维组织。结论自体骨、软骨移植可修复骨软骨缺损,MR可无创性地动态观察修复过程。

Objective To investigate the MRI characterization of cartilage repair after autologous osteochondral transplantation （AOT）. Methods Ten healthy, mature goats were randomly divided into five groups. A cylindrical osteochondral defect was surgically created on the weight-bearing surface in each stifle, and then 3 cylindrical osteochondral grafts from the non-weight-bearing surface were transplanted to the defect with a mosaic fashion. MRI follow-up of dissected stifles was initiated on a 3.0T MR unit （Philips Achieva）. Results The signal intensity of the grafts was the same as that of normal tissue. The repair tissue at early time points appeared as hyperintense and gradually became hypointense. The grafts were basically intact and the defect predominantly comprised fibrocartilage or fibrous tissue histologically. Conclusion AOT can completely fill the osteochondral defect. MRI provides a non-invasive way for monitoring the process of repair after AOT.