心理应激对生殖轴内分泌网络影响的因子分析模型

Factor Analysis Model for Studying the Influence of Psychological Stress on the Endocrine Network of Reproduction Axis

为了探讨心理应激对生殖轴的影响,从动物实验得到的原始生物学数据入手,对生殖轴内分泌网络的6个重要的生物调节因子做因子分析,建立了心理应激下的生殖轴内分泌网络的因子分析模型。对比正常状态下的因子分析模型,发现心理应激状态下的各生物因子之间的调控关系更复杂,集中反映在促性腺激素释放激素(go-nadotropin releasing hormone,GnRH)这个关键因子对各个下层因子调控关系减弱,特别是对雌二醇(estrogen,E2)的调控很弱,而β-内啡肽(-βEndorphin,-βEP)对各个下层因子的调控关系却比正常状态下增强,特别是对E2的调控作用非常强,且E2主要受-βEP控制。

In order to explore the influence of psychological stress on the reproductive axis, we started with the original data of biology from animal experiments, then we conducted the factor analysis of 6 important bio-regulatory factors and established the Factor Analysis Model for the endocrine network of reproduction axis under psychological stress. Based on the biological data obtained from animal experiments, it is found that, compared with the relationship seen in the factor analysis model in normal condition, the relationship among the biological factors is more complicated. The key factor, GnRH, has lost its strong regulating action on the subordinate factors, especially on F：2 ;on the other hand,β-EP has very strong regulating action on E2, and E2 is controlled mainly by β-EP.