世居藏族患者乙肝病毒基因型及其临床特点分析

Tibetan native of hepatitis B virus genotype and clinical characteristics

目的对世居藏族乙肝病毒(HBV)的基因型及其临床特点进行分析。方法对78例世居藏族患者的乙肝病毒基因分型、乙肝病毒DNA定量及其肝功能、两对半、肝纤维化指标、AFP、CEA、腹部B超等进行了检测,并对其临床特点进行分析。结果世居藏族乙肝患者乙肝病毒基因型主要以B型和C型为主,78例患者中B型41例,C型37例,B型和C型构成无统计学差异。C型患者HBVDNA定量、肝功能各指标、肝纤维化指标、AFP、HBe-Ag阳性率、CEA阳性率、肝硬化发生率、肝癌发生率、脾大发生率均显著高于B型患者(P<0.05～0.01)。结论世居藏族乙肝病毒基因型以B型及C型为主,C型患者肝硬化、肝癌发生率及肝纤维化和肝功能损害程度明显要高于B型患者,故在临床对C型世居藏族乙肝患者应加强针对性的防治。

Objective Purpose right native Tibetan hepatitis B virus （HBV） genotype and clinical characteristics were analyzed. Methods Among 78 cases of patients with the native Tibetan HBV gene type, Quantitative analysis of hepatitis B virus DNA and liver function, two pairs of semi - HB, liver fibrosis, AFP, CEA, a B - ultrasonic testing of abdomen, and clinical characteristics were analyzed. Results Native Tibetan hepatitis B genotypes in patients with hepatitis B virus mainly B- and C- type, 78 cases of patients with B-41, C -37, B- and C -type pose no significant difference. C -type HBV DNA in patients with quantitative, the indicators of liver function, liver fibrosis, AFP, HBeAg positive rate, CEA -positive rate, the incidence of cirrhosis, liver cancer incidence, splenomegaly incidence was significantly higher than that in patients with type B （P 〈 0. 05）. Conclusion Native Tibetan HBV genotype mainly B, and C - type, C - type patients with cirrhosis, the incidence of liver cancer and liver fibrosis and liver dysfunction significantly higher than in patients with type B, the C in clinical right - native Tibetan hepatitis B patients should strengthen targeted prevention.