硫普罗宁联合维生素E治疗酒精性脂肪肝疗效的临床观察

A clinical observation on the efficacy of tiopionin combined with Vitamin E for alcoholic fatty liver disease

目的探讨硫普罗宁联合维生素E治疗酒精性脂肪肝(AFL)的临床疗效及安全性。方法72例AFL患者随机分为两组,治疗组(46例)给予硫普罗宁0.2g每日1次静脉滴注、维生素E100mg每日2次口服;对照组(26例)给予葡萄糖醛酸内酯0.6g每日1次静脉滴注、肌苷0.4g每日3次口服。两组疗程均为1个月,观察患者治疗前后的主要症状和体征、药物不良反应、肝功能、血脂及B超下脂肪肝影像变化。结果治疗后两组比较,治疗组的症状和体征较对照组有改善(P<0.01);治疗组总有效率(80.4)高于对照组(46.2)(P<0.01);治疗组AST、ALT、γ-GT、甘油三酯(TG)较对照组降低(P<0.01),两组TBil、总胆固醇(TC)差异无统计学意义(P>0.05);治疗组脂肪肝B超分度变化较对照组有改善(P<0.01)。治疗过程中治疗组出现3例皮疹,2例低热,4例胃肠道反应。结论硫普罗宁联合维生素E治疗酒精性脂肪肝有较好的疗效,在治疗中应观察药物的不良反应。

Objective To study the therapeutic effect and safety of tiopionin eombined with Vitamin E for alcoholic fatty liver （AFL）. Methods 72 patients with AFL were randomly divided into two groups. The treatment group （ n = 46） was treated with 0. 2g tiopionin once daily by intravenous drip and 100mg Vitamin E two daily by orally taken. The control group （ n = 26 ） was given 0. 6g glucurolactone once daily by intravenous drip and 0. 4g inosine three daily by orally taken. The treated course for both group was one month. Before and after treatment, clinical data including main symptoms and signs, adverse drug reactions, hepatic function, blood grease and fatty liver image B uhrasonie wave of the two groups were monitored respectively. Results After treatment the symptoms and signs of the treatment group were better than those of the control group. Total effective rate of the treatment group （80.4%） was higher than that of the control group （46. 2% ） （P 〈 0. 01 ）. The levels of AST, ALT, γ - GT and triglyceride（TG） were more declinced in the treatment group than the control group （ P 〈 0. 01 ）, but there were no significant different for TBil and total cholesterol （TC） bctween the two groups. There were 3 cases of skin eruption, 2 cases of fever and 4 cases of gastrointestinal reaction observed in treatment group. Conclusion Tiopionin combined with Vitamin E has good clinical efficacy for the treatment of alcoholic fatty liver disease, the adverse effects must be observed in treatment.