急性胰腺炎患者血清MCP-1、IL-8动态检测的临床意义

The clinical significance of dynamic changes of MCP-1 and IL-8 levels in patients with acute pancreatitis

目的探讨动态检测血清单核细胞趋化因子蛋白1(MCP-1)、白细胞介素8(IL-8)浓度变化对急性胰腺炎(AP)病情严重度评估的价值。方法AP住院患者101例,其中轻症胰腺炎(MAP组)78例,重症胰腺炎(SAP组)23例。SAP中包括重症胰腺炎无肺损伤(SAPNLI组)13例,急性胰腺炎并相关性肺损伤(APALI组)患者10例。采用ELASA法检测第1、3、7、11天血清MCP-1、IL-8浓度;另选体检健康者40例作为对照。结果(1)入院当日MCP-1血清浓度各组均有明显升高,在MAP组与对照组、SAPNLI组与MAP组、APALI组与SAPNLI组各组间比较均有统计学差异(P<0.05、P<0.01)。入院当日IL-8血清浓度SAPNLI组与APALI组比较存在统计学差异(P<0.01)。(2)各组的MCP-1,IL-8血清浓度水平均第3天达到峰值;(3)入院第3、7、11天的MCP-1、IL-8血清浓度SAPNLI组与MAP组,APALI组与SAPNLI组比较具有统计学差异(P<0.05、P<0.01)。结论动态检测血清MCP-1、IL-8浓度有助于预测AP病情发展,并可能成为预示肺损伤的重要指标。

Objective To evaluate the significance of detecting blood MCP-1 and IL-8 levels in evaluating the severity of the patients with acute pancreatitis（AP）.Methods Serum concentrations of monocyte chemoattractant protein-1（MCP-1） and interleukin-8（IL-8） were detected dynamically by ELISA in 101 acute pancreatitis patients,including 78 mild AP（MAP） patients,13 severe AP without lung injury（SAPNLI） patients,10 AP with lung injury（APALI） patients,and 40 healthy volunteers（controls）.Results（1） On the 1st day,the statistical difference was found in the serum concentration of MCP-1 between MAP cases and controls,SAPNLI cases and MAP cases,SAPNLI cases and APALI cases（P〈0.05）.IL-8 in APALI cases was significantly different from that in SAPNLI cases（P〈0.01）.（2） The levels of MCP-1 and IL-8 in MAP reached the peak level on the 3rd day after admission in all patients.（3）There was a significant statistical difference between SAPNLI cases and MAP cases,APALI cases and SAPNLI cases in the concentration of MCP-1 and IL-8 on the 3rd,7th,11th day after admission（P〈0.01）.Conclusion Dynamic measurement of blood MCP-1 and IL-8 dynamically is useful in evaluating the severity of the patients with AP,and may be taken as a significant marker for predicting the lung injury in AP patients.