罗库溴铵的合成研究

The synthesis of rocuronium bromide

目的合成罗库溴铵。方法以表雄酮为起始原料,经酯化、消除、溴代、环氧化、氨解、还原、开环、选择性乙酰化,最后与烯丙基溴成盐等9步反应合成目标物罗库溴铵。结果与结论罗库溴铵的结构经红外光谱、核磁共振氢谱、质谱、元素分析确证,总收率达24.9%。

Aim To study the synthesis of rocuronium bromide. Methods Rocuronium bromide was synthesized from commercially available epi-androsterone through esterification, elimination, bromination, epoxidation, aminolysis, reduction, ring opening, acetylation and then allylation with allyl bromide. Results and conclusion The target compound was identified by IR, ^1H-NMR, MS and elemental analysis, the overall yield is 24.9%.