2EVANS D A, MITCH C H, THOMAS R C, et al. Application of metalated enamines to alkaloid synthesis. An expedient approach to the synthesis of morphine-based analgesics[J ]. J Am Chem Soc, 1980,102(18) : 5955 - 5956.
3BARNETT C J, COPLEY-MERRIMAN C R, MAKI J. Synthesis of picenadol via metalloenamine alkylation methodology [J ]. J Org Chem, 1989, 54 (20) : 4795 -4800.
4MARON D J, FRY R D. New therapies in the treatment of postoperative ileus after gastrointestinal surgery [ J ]. Am J Ther, 2008, 15 (1) : 59 - 65.
5WEBSTER L, JANSEN J P, PEPPIN J, et al. Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction:results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain [J ]. Pain, 2008, 137(2) :428 - 440.
5Zimmerman DM,Gidda JS.Discovery of a potent peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders[J].J Med Chem,1994,37(15):2262-2265.
6Eistetter K,Wolf H.Synthesis and hypoglycemic activity of phenylalkyloxiranecarboxylic acid derivatives[J].J Med Chem,1982,25(2):109-113.