摘要
目的:评价九通胶囊(葛根、枳椇子等)的毒理学安全性。方法:通过小鼠急性毒性试验、骨髓微核试验、精子畸形试验、Ames试验、30d喂养试验对九通胶囊进行毒性评价。结果:(1)九通胶囊的急性毒性试验LD50大于每千克体重10.0g,表明属无毒级样品;(2)Ames试验、骨髓微核试验、精子畸形试验均为阴性结果;(3)30d喂养试验显示九通胶囊无毒性,无体内蓄积中毒。结论:九通胶囊属无毒级产品,无致突变作用,无遗传毒性,无明显体内蓄积中毒。
AIM： To estimate the toxicological characterization of Jiutong Capsule （Radix Puerariae lobatae, Fructus seu Semen Hoveniae, etc. ）. METHODS： The acute toxicity test, micronucleus test of bone marrow cell, sperm shape abnormality test in mice, the Ames test, and 30 days feeding test in rat were performed. RESULTS： （ 1 ） The acute toxicity test showed that LDso of Jiutong Capsule was more than 10.0 g/kg. （2） The result of Ames test, micronucleus test of bone marrow cell, and sperm shape abnormality test were negative. （3） The 30 days feeding test showed that Jiutong Capsule had no cumulate toxicity in mice. CONCLUSION： The results show that Jiutong Capsule does not have toxicity, and it can＇t cause mutation and heredity toxicity.
出处
《中成药》
CAS
CSCD
北大核心
2008年第12期1740-1744,共5页
Chinese Traditional Patent Medicine
关键词
九通胶囊
急性毒性
遗传毒性
小鼠
Jiutong Capsule
acute toxicity
heredity toxicity
mouse
