取代咪唑酮合成工艺研究

Study on the synthesis of replaced imidazole

目的:优化取代咪唑酮类化合物的合成工艺。方法:采用正交设计法,重点考察反应溶剂,投料比例及温度对收率的影响。结果:投料比例对收率的影响最为显著。结论:使收率由低于10%提高到42.5%,使得更加符合工业生产的要求。

Objective ： To optimize the synthesis of replaced imidazole. Methods ： Orthogonal experimental design was used and the influence of temperature, reactant ratio and solvent on the yield were investigated. Results ： Reactant ratio was more important than the others. The yield was improved from less than 10% to 42.5%. Conclusion：The optimal preparation procedure is stable and available for industrial production.