国内HPV16感染与宫颈癌发病风险的Meta分析

META-ANALYSIS OF THE RELATIONSHIP BETWEEN HPV INFECTION AND THE RISK OF CERVICAL CANCER IN CHINA

[目的]利用Meta分析来评价人乳头状病毒HPV16感染与宫颈癌发病风险的关系。[方法]检索1990～2006年中国期刊网、维普科技期刊网等,追溯检索已发表的论文文献,纳入标准为涉及HPV16感染与宫颈癌发病风险评估的独立病例对照研究。[结果]将14个研究结果加权合并,累计病例1544例,HPV感染率47.80%;累计对照695例,HPV感染率11.08%;合并OR=9.30(95%CI:4.11～21.01)。[结论]国内HPV16感染与宫颈癌发病有关联,HPV16感染增加了宫颈癌的发病危险性。

[Objective] To evaluate the relationship between HPV16 infection and the risk of cervical cancer in China by meta-analysis. [ Methods ] Published literatures from 1990 to 2006 on HPV 16 infection and cervical cancer were collected from CNKI, VIP databases and so on. including criterions were independent case control study about the evaluation of HPV16 infection and the risk of cervical cancer. [Results] Results of 14 studies were weighted and pooled, a total of 1544 cases and 695 controls were collected, the HPV16 infection rates of cases and controls were 47.80% and 11.08%, respectively. Aggregated odds ratio was 9.30 （95%CI： 4.11-21.01）. [Conclusien] HPV16 infection was associated with the incidence of cervical cancer in China, and HPV16 infection increased the risk of cervical cancer.