糖耐量减低人群胰岛素抵抗和胰岛β细胞功能特点分析

ANALYSIS OF INSULIN RESISTANCE AND PANCREATIC B-CELL FUNCTION IN THE POPULATION WITH IMPAIRED GLUCOSE TOLERANCE

[目的]探讨糖耐量减低(IGT)人群胰岛素抵抗和胰岛β细胞功能的特点。[方法]根据口服75克葡萄糖耐量试验(OGTT),将30～60岁的222例患者分为糖耐量正常(NGT)组和糖耐量减低(IGT)组,利用HOMA模型胰岛素抵抗指数(HOMA-IR)和β细胞功能指数(HBCI)进行分析。[结果]与NGT人群相比,IGT人群体重指数、腰臀比、甘油三酯、血压、空腹胰岛素、OGTT2h胰岛素、HOMA-IR明显升高,HBCI明显降低,2组比较差异均有统计学意义(P﹤0.01)。[结论]与NGT人群相比,IGT人群已有胰岛素抵抗及胰岛β细胞受损,且IGT人群有着更高的BMI、WHR、TG、SBP及DBP等衡量胰岛素抵抗的临床指标。

[Objective] To investigate the characteristics of insulin resistance （IR） and β-cell function among people with Impaired Glucose Tolerance （IGT）. [Methods] According to oral 75g glucose tolerance test （OGTT）, 222 subjects aged 30-60 years were divided into normal glucose tolerance （NGT） group and impaired glucose tolerance （IGT） group. IR index （HOMA-IR） and β-cell function index （HBCI） of Homa model were applied to assess the status of IR and B cell function in two groups. [Results] Compared with the NGT group, the body mass index, waist - to-hip ratio, serum triglyeefide, blood pressure, fasting plasma insulin, OGTT 2h insalin and HOMA-IR were significantly higher than those in IGT group, while the HBCI were significantly lower （P 〈 0.01 ）. [ Conclusion] Insulin sensitivity and β-cell function infasting status were significantly worse in IGT group than those in NGT group. Also. The BMI, WHR, TG, SBP and DBP which could measure the insulin resistance were more significant in people with IGT.