摘要
用ADP引起兔血小板脱敏,测定血小板上ADP受体的K_D及数目,并与正常血小板上的数据比较。正常血小板的K^D=0.0129nM,受体数=857.69;而脱敏血小扳的K′_D=0.0265nM,受体数=294.78。以上结果说明由于细胞表面受体的内化,使受体亲和力及受体数目减少。
By using ADP desensitized rabbit platelets, the determination of KD and ADP receptor numbers in desensitized platelets were investigated, and compared with that of normal ones. In normal platelets, KD = 0.0129nM, number of receptors = 857.69; while in desensitized platelets, KD = 0.0265 nM, number of receptors= 294.78. these results indicate that desensitization leads to a reduction in receptor affinity and receptor number due to interaalization of cell surface receptors.
出处
《基础医学与临床》
CSCD
1990年第1期36-40,共5页
Basic and Clinical Medicine
基金
国家自然科学基金
关键词
脱敏
ADP
受体
血小板聚集
调节
desentization ADP receptor platelet aggregation binding curve