糖化血红蛋白及血小板参数联合检测在糖尿病患者微血管病变时的意义

THE SIGNIFICANCE OF THE UNITED DEMERMINATION OF GLYCOSYLATED HEMOGLOBIN AND PLATELET PARAMETERS IN MICROANGIOPATHY OF THE DIABETIC

目的探讨糖化血红蛋白(HGb)及血小板参数联合检测在糖尿病患者微血管病变时的意义。方法采用全自动血细胞分析仪和生化分析仪检测79例糖尿病(DM)患者(有微血管病变者40例,无微血管病变者39例)的GHb、PLT、MPV、PDW,与40例健康成人(对照组)进行对照比较。结果有微血管病变组GHb、MPV、PDW明显高于无微血管病变组及对照组(P<0.01);对照组的PLT与糖尿病患者比较无统计学意义(P>0.05)。结论GHb与血小板参数的联合检测对糖尿病患者微血管病变的早期诊断具有重要价值。

Objective To explore the significance of the united detemination of glycosylated hemoglobin（GHb） and platelet parameters in microangiopanthy of the diabetics.Methods GHb mean platelet volumer （MPV）,platelet distribution width（PDW） and platelet count in 79 diabetics（40cases with miecroangiopathy and 39 cases without microangiopathy）and 40 heathy controls were determined by automatic blood and bicohemistry cytoanalyzers.Results GHb,MPV and PDW in diabetic patients were significantly higher than those in controls（P〈0.01）,and those in patrients with microangiopathy were significantly highter than those in patiets without microangiopathy（P〈0.01）.There was no obvious difference in PLT between diabetic patients and contorls（P〉0.05）.Conclusion The united determination of GHb and platelet parameters could play a important role in early diagnosis of microangiopathy of the diabetics.