米力农佐治老年顽固性心力衰竭60例疗效观察

THE CURATIVE EFFECTS OF MILRINONE ON SENILE REFRATORY HEART FAILURE

目的观察米力农佐治老年顽固性心力衰竭的疗效及其对血浆B型脑钠肽(BNP)浓度的影响。方法将118例老年顽固性心力衰竭患者随机分为治疗组和对照组。治疗组60例,在常规治疗的基础上加用米力农,首剂负荷量50μg/(kg.min),缓慢推注10 min,再以0.5μg/(kg.min)静脉滴注,时间4 h,1次/d。7 d为1疗程。对照组58例,给予常规药物治疗。治疗前后均测其血浆BNP浓度、左室射血分数(LVEF)及左室舒张末径(LVEDD)变化。结果疗效:观察组总有效率95%,对照组为60.34%,观察组高于对照组(χ2=20.62,P<0.01);两组治疗后LVEF及LVEDD比较均有统计学意义(t=10.46,4.61,P<0.01);两组治疗后血浆BNP浓度有统计学意义(t=20.83,P<0.01)。结论米力农短期应用治疗老年顽固性心力衰竭安全有效。

Objective To explore the curative effects of milrinone on senile refratory heart failure （SRHF） and its effects on the concentration of brain natriuretil peptide （BNP） in Type B blood. Methods 118 cases of SRHF were randomly divided the treatment group and the contrast group. The 60 cases in the treatment group were treated with milrinone [ first close of 50μg/（kg· min）] first for 10 minutes and then with milrinone [0.5μg/（kg· min） ] 4 hours, once a day, 7 days as a course in addition to routine treatment. The contrast group was given routine treatment.The left ventricular ejection fraltion （LVEF） and the left ventricular end-diastolic diameter （LVEDD） and the concentration of BNP were examined before and after treatment. Results The total effective rates in the treatment group and the contrast group were 95 % and 60.34 % respectively （χ^2= 20.62, P 〈 0.01）. There existed significant differences in LVEF and LVEDD before and after treatment in both groups（ P = 10.46,4.61 ; P 〈 0.01）. There existed significant differences in BNP between the two groups after treatment （ t = 20.83; P （0.01）. Conclusion Milrinone can be used as adjutant to treat seinile refractory heart disease effective and safely.