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表观遗传修饰与前列腺癌 被引量：2

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摘要 表观遗传是指DNA序列不发生变化但基因表达却发生了可遗传的改变。表观遗传的分子生物学机制包括四个方面：DNA的甲基化、基因印记、RNA干扰和组蛋白修饰。各种因素可以通过影响表观遗传，进而对前列腺癌的发病起作用。
作者 李涛 黄翼然 李东
机构地区 上海交通大学附属仁济医院泌尿外科
出处 《实用医学杂志》 CAS 2008年第23期4141-4142,共2页 The Journal of Practical Medicine
关键词 表观遗传修饰 前列腺癌 分子生物学机制 DNA序列 组蛋白修饰 RNA干扰 基因表达 基因印记
分类号 R737.25 [医药卫生—肿瘤]
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参考文献23

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同被引文献9

  • 1Ito Y, Miyazono K. RUNX transcription factors as key targets of TGF-beta superfamily signaling [J]. Curr Opin Genet Dev, 2003,13( 1 ) :43-47.
  • 2Nosho K, Shima K, Irahara N, et al. DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer [J]. Clin Cancer Res, 2009,15 ( 11 ) : 3663-3671.
  • 3Gao F, Huang C, Lin M, et al. Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas [J]. J Cancer Res Clin Oncol, 2009, 135(5) :739-747.
  • 4Okuda T, van Deursen J, Hiebert S W, et al. AML1 the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis [J]. Cell, 1996,84 (2) :321-330.
  • 5Banerjee C, McCabe L R, Choi J Y, et al. Runt homology domain proteins in osteoblast differentiation: AML3/CBFA1 is a major component of a bone-specific complex [J]. J Cell Biochem, 1997,66( 1 ) : 1-8.
  • 6Subramaniam M M, Chan J Y, Yeoh K G, et al. Molecular pathology of RUNX3 in human carcinogenesis [J]. Biochim Biophys Acta, 2009,1796(2) :315-331.
  • 7何晶晶,毛易捷,许刚,吴伟,陶志华,沈默,吴秀玲,陈占国,周武.前列腺癌组织中GSTP1和DAPK基因异常甲基化检测及临床意义[J].实用医学杂志,2009,25(9):1362-1364. 被引量：6
  • 8Alexander W Wyatt,Fan Mo,Yuzhuo Wang,Colin C Collins.The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing[J].Asian Journal of Andrology,2013,15(3):301-308. 被引量：5
  • 9Mingquan Sha,Genxiang Mao,Guofu Wang,Yufeng Chen,Xiaojian Wu,Zhen Wang.DZNep inhibits the proliferation of colon cancer HCT116 cells by inducing senescence and apoptosis[J].Acta Pharmaceutica Sinica B,2015,5(3):188-193. 被引量：10

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实用医学杂志
2008年 第23期

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