无创通气联合纳洛酮抢救海洛因中毒致急性呼吸衰竭临床体会

Clinical Experience of Non-invasive Ventilation Combined With Naloxone in Rescuing Acute Respiratory Failure Caused by Heroin Intoxication

目的:总结无创通气抢救海洛因中毒致急性Ⅱ型呼吸衰竭的治疗经验。方法:15例海洛因中毒致急性Ⅱ型呼吸衰竭患者在常规纳洛酮治疗的同时予以面罩机械通气,并与同期气管插管患者的疗效比较。结果:15例患者经通气治疗1～4h后神志转清,通气2h后动脉血气明显改善、平均通气时间3.6h,通气结束后24h动脉血气基本正常,与气管插管患者无显著差异(P>0.05)。结论:无创通气联合纳洛酮能够快速纠正海洛因中毒致急性Ⅱ型呼吸衰竭,临床疗效肯定,并发症少。

Objective：To summarize the clinical experience of non-invasive mechanical ventilation via facial mask or patients with acute type Ⅱ respiratory failure caused by heroin intoxication. Methods： Fifteen patients with acute type Ⅱ respiratory failure caused by heroin intoxication were received non-invasive mechanical ventilation via facial mask together with regular naloxone treatment. Therapeutic effect was compared with that of a group of patients at same period treated by invasive mechanical ventilation via tracheal intubation. Results： All 15 patients treated by non-invasive ventilation regained their consciousness in 1 to 4 hours. Their arterial blood gases improved significant- ly in 2 hours. The mean ventilation time was 3. 6 hours. Twenty four hours after completion of ventilation, their ar terial blood gases returned to normal. These results showed no significant differences compared with those of patients treated by invasive mechanical ventilation （P〉0. 05）. Conclusion： Non-invasive ventilation combined with naloxone is a practical treatment to cure acute type Ⅱ respiratory failure caused by heroin intoxication.