实体肿瘤血管生成和肿瘤生长的耦合研究

Coupled Study of Tumor Induced Angiogenesis and Tumor Growth

研究宏观尺度上肿瘤向外浸润式生长的动态变化对微观尺度上肿瘤内部微血管网生成过程产生的影响。建立肿瘤组织生长动力学模型与促血管生成的二维离散数学模型,模型考虑促血管生成因子诱导下血管内皮细胞的随机性、趋化性和趋触性运动以及血管内皮细胞与胞外基质的相互作用,并且肿瘤组织的生长满足经典的Compertz函数形式,通过耦合研究模拟了肿瘤组织动态生长过程中微脉管系统生成的时空演化,数值生成肿瘤动态生长下内外异构的微血管网和肿瘤内部分层的网络结构。该模型可以产生相对真实的具有接近肿瘤病理生理特性的血管网,为临床研究提供有益的信息。

The tumor induced angiogenesis was investigated under the influence posed by tumor dynamic growth. A coupled ＂macroscopical tumor dynamic growth-microscopic vascular network formation＂ mathematical model was built to simulate physiological process of tumor induced angiogenesis. The model assumes that the endothelial cells migrate through random motility, chemotaxis and haptotaxis in the extracellular matrix, and the tumor growth complies with previously classical Compertz function. The simulation results show that the relatively realistic tumor microvascular network with neoplastic layered structures and heterogeneous characteristics can be generated from the present model. Moreover, the theoretical capillary networks generated by computer simulations of the coupled model may show the details of the development process between microvascular network and tumor growth and provide the beneficial information for further clinical research.