摘要
目的了解齐拉西酮治疗慢性精神分裂症的疗效及安全性。方法100例慢性精神分裂症患者随机分为两组(齐拉西酮组50例,氯氮平组50例),观察组以齐拉西酮治疗8周的起效时间、疗效及不良反应情况与氯氮平相比较,分别在治疗0、1、2、4、8周评定PAN SS和TESS量表,在0、2、4、6、8周末检查血常规、心电图和肝肾功能。结果齐拉西酮与氯氮平疗效相当,齐拉西酮能迅速减轻精神症状,不良反应少,严重程度轻。结论齐拉西酮治疗精神分裂症安全有效。
Objective To observe the clinical effect and safety of zipraside in the treatment of chronic schizophrenia. Methods 100 patients with chronic .schizophrenia were randomly divided into two groups （zipraside group, 50cease, clozapine group, 50case） receiving respectively for 8 weeks. The curative effects, the time of effects and the side effect of the zipraside group were compared with the clozapine group. PANSS and TESS were rated at baseline and 1, 2, 4, 8 weeks after treatment, Blood, ECG, hepatic and renal funution were examined at baseline and 2, 4, 6, 8 weeks after treatment. Results Both drugs had comparable efficacy. Zipraside relieved psychotic symptoms more rapidly with less and mild side effect and less prolaction change. Conclusion zipraside shows efficacy and safety in treatment of chronic schizophrenia.
出处
《中国健康心理学杂志》
2008年第12期1389-1390,共2页
China Journal of Health Psychology
