不同类型心房颤动患者血清hs-CRP、IL-6水平及临床意义

The clinical significance of high sensitive C-reactive protein and interleukin-6 in types of atrial fibrillation.

目的探讨超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)、白细胞介素6(Interleukin-6,IL-6)在心房颤动(atrial fibrillation,Af)中的水平及临床意义。方法应用免疫法测定100例Af患者(Af组)血清hs-CRP、IL-6水平,与非Af患者(对照组)20例比较;并对Af按持续时间不同分组,进行统计学分析。结果 Af组血清hs-CRP、IL-6水平明显高于对照组;持续性、永久性Af组hs-CRP、IL-6水平无显著性差异,持续性、永久性Af组hs-CRP、IL-6水平均高于阵发性Af组。结论血清hs-CRP、IL-6水平增高反映的炎症状态可能促进房颤发生和发展。

Objective To evaluated the effect of hs - CRP, IL - 6 on pathogenesis of different categories of AF. Methods The immunochemistry method was used to determine the serum hs - CRP,IL -6 concentration in 100 Af patients whose were divided according to the lasting paroxysm of Af. Results The level of serum hs -CRP,IL- 6 in Af patients was higher than that in control group. There was no difference between the level of serum hs - CRP,IL - 6 in persistent and permanent Af cases. The level of serum in other groups was higher than that in paroxysmal Af, respectively. Conclusion The inflammatory state, reflected by the elevation of the level of serum hs -CRP,IL- 6 level, may promote the occurance and persistence of Af.