摘要
丙戊酸盐类抗癫痫药物是治疗癫痫的常用药物,也用于精神疾病的辅助治疗。该药可诱发脑病,常发生在服药早期,停药可使症状消失。典型的临床表现为癫痫发作加重、意识障碍、共济失调及扑翼样震颤。本文报道1例在服用丙戊酸钠后发生丙戊酸脑病(valproate encephalopathy,VPE)的病案。
出处
《中国医学创新》
CAS
2008年第34期150-150,共1页
Medical Innovation of China
参考文献5
-
1张小澍,鱼爱和.药源性神经系统疾病(一)[J].药物不良反应杂志,2005,7(3):203-208. 被引量:10
-
2Marie-José C.C. Dealberto.Valproate-induced hyperammonaemic encephalopathy: review of 14 cases in the psychiatric setting[J].International Clinical Psychopharmacology.2007(6)
-
3P. Parize,P. Beuret,C. Fischer.Une encéphalopathie au valproate sans hyperammoniémie[J].Annales francaises d’anesthesie et de reanimation.2007(12)
-
4Wadzinski J,Franks R,Roane D,et al.Valproate-associated hyperammonemic encephalopathy[].J Am Board Fam Med.2001
-
5Alqahtani S,Federico P,Myers RP.A case of valproate-induced hyperammonemic encephalopathy:look beyond the liver[].Canadian Medical Association Journal.2007
共引文献9
-
1陈赟,周斌,詹秀琴.药物免疫促进剂与抑郁症相关性探讨[J].浙江中西医结合杂志,2006,16(7):455-457.
-
2张小澍,鱼爱和.可逆性后部白质脑病综合征及相关药物[J].药物不良反应杂志,2008,10(1):47-53. 被引量:7
-
3刘宇,张媛媛,吴亦美,赵秀丽,张小澍.丙戊酸钠相关高血氨脑病1例报告及文献回顾[J].药物不良反应杂志,2009,11(3):203-205. 被引量:4
-
4李锦,李青,龙志新.药物性帕金森综合征研究进展[J].医学信息(下旬刊),2010,23(10):90-90.
-
5霍记平,李新刚,余克富,赵志刚.药源性神经毒性及其生物标志物的研究进展[J].药品评价,2014,11(18):9-10. 被引量:1
-
6朱莎莎.顽固性癫痫术后丙戊酸钠脑病1例临床护理[J].齐鲁护理杂志,2015,21(18):105-106.
-
7韩鹏,朱深银.药源性周围神经病变的发生机制、临床特点及防治[J].药物不良反应杂志,2018,20(2):128-134. 被引量:4
-
8焦淑洁,刘亚玲,岳培建,李莉.望江南子致周围神经病一例报道并文献复习[J].中华神经医学杂志,2019,18(9):949-951. 被引量:1
-
9卢京川,王嘉熙,郭代红,袁拥华,伏安,李超,郭海丽,李伯研,张博.863例药物相关严重神经系统不良反应自发报告分析[J].药物流行病学杂志,2022,31(7):444-447. 被引量:3
同被引文献26
-
1Jaksch M, Klopstock T, Kurlemann G, et al. Progressive myoclonus epilepsy and mitochondrial myopathy associated with mutations in the tRNA (Ser (UCN)) gene.Ann Neurol,1998,44:635-640.
-
2Canafoglia L, Franceschetti S, Antozzi C, et al. Epileptic phenotypes associated with mitochondrial disorders. Neurology,2001,56:1340-1346.
-
3Dickerson BC,Hohzman D,Grant PE,et al.Case records of the Massachusetts General Hospital. Case 36-2005. A 61-year-old woman with seizure,disturbed gait,and altered mental status.N Engl J Med,2005,353:2271-2280.
-
4Shoffner JM. Mitochondrial myopathy diagnosis. Neurol Clin,2000,18:105-123.
-
5Simon DK, Johns DR. Mitochondrial disorders: clinical and genetic features.Annu Rev Med,1999,50:111-127.
-
6Nakamura M,Yabe I,Sudo A,et al.MERRF/MELAS overlap syndrome:a double pathogenic mutation in mitochondrial tRNA genes.J Med Genet,2010,47:659-664.
-
7Aharoni S,Traves TA,Melamed E,et al. MELAS syndrome associated with both A3243G-tRNALeu mutation and multiple mitochondrial DNA deletions.J Neurol Sci,2010,296:101-103.
-
8Michelson D J,Ashwal S.The pathophysiology of stroke in mitochondrial disorders.Mitochondrion,2004,4:665-674.
-
9Ohama E,Ikuta F.Involvement of choroid plexus in mitochondrial encephalomyopathy(MELAS).Acta Neuropathol,1987,75:1-7.
-
10Iizuka T,Sakai F.Pathogenesis of stroke-like episodes in MELAS:analysis of neurovascular cellular mechanisms.Curt Neurovasc Res,2005,2:29-45.
二级引证文献3
-
1李秋凤,陈阳美,曾可斌,肖飞,洪思琦.线粒体脑肌病11例临床分析[J].癫痫杂志,2016,2(1):18-23. 被引量:1
-
2张晓,王朝霞,刘凤君,邓馨,于磊,王薇薇,袁云.线粒体脑肌病伴高乳酸血症和卒中样发作的癫痫发作及脑电图特点分析[J].中华神经科杂志,2014,47(5):336-340. 被引量:14
-
3时宏娟,牟英峰,陈浩,王小鹏,郝敬波.MELAS综合征一家系5例报告及特点分析[J].徐州医学院学报,2014,34(12):889-892. 被引量:1
-
1汪超甲,王辉.丙戊酸钠相关性高血氨脑病1例报道并文献复习[J].国际神经病学神经外科学杂志,2016,43(6):557-559. 被引量:1
-
2董继宏,秦震,张宇浩.丙戊酸钠诱发的高血氨[J].中国临床神经科学,2000,8(4):259-259. 被引量:1
-
3俞月婷,林一嫦,施玉琼.高血氨性脑病2例护理[J].中国乡村医药,2016,23(7):85-85.
-
4张玲娣,戴海斌.1例丙戊酸钠所致高血氨脑病的案例分析[J].中国现代应用药学,2016,33(9):1202-1204. 被引量:3
-
5周利民.肝性脑病24例临床分析[J].泸州医学院学报,2002,25(3):224-225.
-
6郝志明.幽门螺杆菌感染与肝性脑病[J].临床肝胆病杂志,2000,16(2):86-88.
-
7孙振晓,于相芬.丙戊酸钠引起高血氨性脑病1例[J].药物流行病学杂志,2013,22(5):278-279. 被引量:3
-
8陈亚南,张媞,徐善森,刘美,杨帆,肇丽梅.丙戊酸钠联用新型抗癫痫药对癫痫患儿血氨的影响[J].中国临床药理学杂志,2016,32(15):1378-1380. 被引量:22
-
9李仓霞,薛海龙,蒲晓龙,肖文,王军文,郭小峰.拉莫三嗪治疗月经相关性癫痈的体会[J].癫痫与神经电生理学杂志,2013(2):122-123.
-
10李锐,范小琴,汪咏秋,张克翰.6例丙戊酸钠脑病患者临床分析[J].中国急救医学,2012,32(6):568-570. 被引量:4