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巨噬细胞炎症蛋白1α在多发性骨髓瘤高表达及其意义

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摘要 巨噬细胞炎症蛋白1α(Macrophage inflammatory protein-1α,MIP-1α)是一种低分子量的趋化因子CC亚族成员。近年来研究表明,MIP-1α在多发性骨髓瘤(multiple myeloma,MM)中呈高表达,并有激活破骨细胞和促MM细胞增殖迁移的病理生理作用。
作者 李舍予 田报春 付蓉
机构地区 四川大学华西临床医学院 四川大学华西基础医学与法医学院 天津医科大学总医院血液科
出处 《西部医学》 2009年第1期137-138,共2页 Medical Journal of West China
关键词 巨噬细胞炎症蛋白1Α 多发性骨髓瘤 破骨细胞
分类号 Q51 [生物学—生物化学] R733.3 [医药卫生—肿瘤]
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  • 1HASHIMOTO T,ABE M,OSHIMA T,et al.Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta correlates with lytic bone lesions in patients with multiple myeloma[J].Br J Haematol,2004,125(1):38-41.
  • 2LENTZSCH S,GRIES M,JANZ M,et al.macrophage inflammatory protein -1α triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma cells[J].Blood,2003,101(9):3568-3573.
  • 3MICHAEL G.ALEXANDRAKIS A,FREDA H,et al.Evaluation of bone disease in multiple myeloma:a correlation between biochemical markers of bone metabolism and other linical parameters in untreated multiple myeloma patients[J].Clinic Chim Acta,2002,325(1-2):51-57.
  • 4OYAJOBI B O,FRANCHIN G,WILLIAS P J,et al.Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease[J].Blood,2003,102(1):311-319.
  • 5ABE M,HIURA K,WILDE J,et al.Role for macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in the development of osteolytic lesions in multiple myeloma[J].Blood,2002,100(6):2195-2202.
  • 6UNEDA S,HATA H,MATSUNO F,et al.Macrophage inflammatory protein-1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM[J].Br J Haematol,2003,120(1):53-55.
  • 7TERPOS E,POLITOU M,VINIOU N,et al.Significance of macrophage inflammatory protein-1 alpha (MIP-1alpha) in multiple myeloma[J].Leuk Lymphoma,2005,46(12):1699-1707.
  • 8MOLLER C,STROMBERG T,JUREMAM M,et al.Expression and function of chemokine receptors in human multiple myeloma[J].Leuke,2003,17(1):203-210.
  • 9OBA Y,LEE J W,EHRLICH L A,et al.MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells[J].Exp Hematol,2005,33(3):272-278.
  • 10Lentzsch S.Gries M,Janz M,et al.Macrophage inflammatory protein 1-alpha (MIP-1α) triggers migration and signaling cascades mediating surival and proliferation in multiple myeloma(MM) cells[J].Blood,2003,101(9):3568～3573.

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西部医学
2009年 第1期

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