酚磺乙胺致过敏性休克13例文献分析

Literature analysis of ethamsylate-induced anaphylactic shock in 13 cases

目的探讨酚磺乙胺引起过敏性休克的特点和转归,为临床安全用药提供参考。方法利用"中文期刊全文数据库"、"中文科技期刊全文数据库"和"万方数据医药信息镜像系统",对1994～2007年9月国内医药学期刊发表的文献进行全面检索,检索到酚磺乙胺致过敏性休克病案13例,对病例的资料进行整理、统计与归纳。结果男性8例(61.5%),女性5例(38.5%);均为常规剂量静脉滴注、静脉注射或肌肉注射;过敏反应多发生在用药后5min以内(58.3%);13例患者经抢救治疗后全部恢复。结论通过本文文献分析,为酚磺乙胺用药安全提供参考。

Objective To discuss the characteristics and outcome of ethamsylate-induced anaphylactic shock,and provide reference for clinical safe drug use. Methods The literature between January 1994 and September 2007 was retrieved from Chinese Journal Full-text Database,Chinese Science and Technology Journal Full-text Database,and Wanfang Medicine Data China info. Thirteen cases with ethamsylate -induced anaphylactic shock were collected and analyzed. Results Of the 13 cases, 8 （61.5%）were male, 5 （38.5%） were female.They were intravenousin fusion or intravenous injection or intramuscular injection.Larger percentage of anaphylactic shock occurred within 5 minutes （58.3%） after administration. Conclusion This paper provided reference for the safe medication of ethamsylate.