头孢呋辛和头孢他啶对耐药鲍曼不动杆菌抗生素后效应实验观察

Study the PAE of Cefuroxime and Ceftazidime to the drug-resistant acinetobacter baumanii

目的观察研究头孢呋辛和头孢他啶对院内感染常见致病菌—多重耐药鲍曼不动杆菌的抗生素后效应(PAE)。方法在不同药物浓度作用下,采用平板倾注法CFU计数,按PAE=T-C计算之,T定义为试验管CFU/m高于重建后0时的10倍(1logCFU/ml)所需时间(min),C为对照管CFU/ml上升10倍所需要的时间(min)。结果4倍MIC无明显PAE,10倍MIC也无明显PAE。结论头孢呋辛和头孢他啶对耐药鲍曼不动杆菌无明显PAE。

Objective To study the PAE that Cefuroxime and Ceflazidime to the drug-resistant acinetobaeter baumanii（Ab）. Methods At different concentration, pourplate and count the colonies. Then calculate from PEA=T-C. ＂T＂ was defined the time （min） the contrast test tube＇s CFU/ml going up 10 times needs. Results There was no obvious PAE when 4 times MIC, and there was also no obvious PAE when 10 times MIC. Conclusion Cefuroxime and Ceftazidime have no obvious PAE to drug-resistant Ab.