金果榄对实验性应激性胃溃疡的保护作用及其机制

Study on the effect of Jinguolan on experimental stress gastric ulcer and mechanism

目的:探讨金果榄对应激性胃溃疡的影响及其作用机制。方法:采用水浸拘束法建立大鼠应激性胃溃疡模型,分别给予金果榄水煎剂和雷尼替丁胶囊常规剂量,给药3d后,第4天造模并解剖大鼠。测定溃疡指数、溃疡抑制率;对溃疡组织进行病理组织学观察;眼球取血并检测血清前列腺素E2(PGE2)和一氧化氮水平(NO)。结果:金果榄治疗组及雷尼替丁治疗组溃疡指数显著降低,溃疡抑制率、血清前列腺素E2和一氧化氮水平明显升高,与模型组相比差异有显著性(P<0.05)。结论:金果榄可促进溃疡愈合,其作用机制可能与促进一氧化氮合成,促进前列腺素E2释放从而调节黏膜血流量的作用有关。

OBJECTIVE To study the effect and mechanism of experimental stress gastric ulcer of Jinguolan. METHODS The rat models of stress gastric ulcer were established by soaking guinea-pig, and the two models groups were separatly treated 3 days with Jinguolan and ranitidine, the ulcer index and the inhibitory were measured; the pathology histology of the ulcer tissues was observed; the level of PGE2 and NO of blood serum was tasted. RESULTS In Jinguolan and ranitidine groups, the ul cer index was obviously decreased, the ulcer inhibitory and the level of PGE2 and NO of blood serum were obviously increased, Compared the medicine groups with the control group, there were obvious difference between the two groups. CONCLUSION Jinguolan has the effect of promoting con crescence of ulcer,and the mechanism may relate to the effect of promoting. NO and releasing PGE2 to regulate blood flux mucous membrane.