葡萄膜炎相关细胞因子与趋化因子基因多态性的研究进展(英文)

Advances in the studies on cytokine and chemokine gene polymorphisms associated with uveitis

葡萄膜炎是一组累及虹膜、睫状体、脉络膜或三者同时受累的炎症性病变。尽管目前对葡萄膜炎的诊断和治疗有了很大的进展,仍有35%～45%患者视力最终丧失。其病因和发病机制仍不太清楚,可能与环境及免疫遗传因素有关。很多研究显示人类组织相容性抗原基因多态性在葡萄膜炎的发病中起重要作用;近年来,非人类组织相容性抗原基因包括细胞因子和趋化因子基因亦被报道在葡萄膜炎的发病机制中起重要作用。本文对葡萄膜炎相关的细胞因子和趋化因子基因多态性的研究进展进行综述。

Uveitis is an inflammation of any or all parts of the uveal tract including the iris, ciliary body and the choroid. Despite current advances in diagnosis and management, visual loss occurs in 35%-45% of patients with uveitis. The etiopathogenesis of uveitis remains unknown; it may be associated with environmental and immunogenetic factors. Many studies have demonstrated polymorphisms in major histocompatibility complex （MHC） genes may determine involvement in uveitis. Recently polymorphisms in non-MHC genes, including cytokine and chemokine genes, have been reported to play important roles in the pathogenesis of uveitis. This article reviewed the advances in the studies on cytokine and chemokine gene polymorphisms associated with uveitis.