视网膜母细胞瘤—发展中国家治疗中的挑战(英文)

Retinoblastoma-challenges of management in a dveloping country

目的:回顾发展中国家在治疗视网膜母细胞瘤中的挑战。方法:回顾1998-01/2002-12,埃努古的尼日利亚大学教学医院和Ebrans临床中心的视网膜母细胞瘤患者的临床及组织病理学资料。结果:总共34例通过组织学被确诊为视网膜母细胞瘤患者。男25例(74%),女9例(26%),男女比例为1∶0.4。平均年龄2.9±1.5岁(5mo～7岁)。6例(18%)患者为双眼发病,28例(82%)为单眼。所予以的治疗为眼内容物剜除术或眼球摘除术联合化疗。结论:在发展中国家,由于患者未及时就诊、贫穷、医疗资源匮乏等因素,视网膜母细胞瘤的治疗现状很差。改善其在发展中国家的治疗,应包括健康教育、早期诊断及提供现代化治疗设施。

AIM： To review the challenges of managing retinoblastoma in a developing country. METHODS： The clinical and histopathological records of patients with retinoblastoma seen at University of Nigeria Teaching Hospital and Ebrans clinic both in Enugu, Nigeria over a 5-year period （January 1998 to December 2002） were reviewed. RESULTS： There were a total of 34 patients with histologically proven retinoblastoma. There were 25 （74%） males and 9（26%） females, giving a male/female ratio of 1：0.4. The mean age was 2.9 ± 1.5 years with a range of 5months-7years. Six patients （18%） had bilateral presentation while 28 （82%） had unilateral presentation. Treatment options offered were enucleation or exenteration combined with chemotherapy. CONCLUSION： Retinoblastoma has suffered from poor management in developing countries due to late presentation, poverty and inadequate facilities. Health education, early diagnosis and provision of modern treatment facilities will go a long way in improving the management of retinoblastoma in developing countries.