摘要
βγ-晶状体蛋白是主要分布于脊椎动物眼睛晶状体内的水溶性结构蛋白。非晶状体βγ-晶状体蛋白从微生物到高等哺乳动物都有过报道。微生物中发现的非晶状体βγ-晶状体蛋白主要作为环境胁迫应急蛋白,在恶劣环境中发挥对细菌的自我保护作用,如ProteinS。在哺乳动物中,非晶状体βγ-晶状体蛋白被推测能够参与胚胎的皮肤发育与分化调节,具有肿瘤抑制等重要的生理功能,如黑色素瘤缺失蛋白。但是,对于它们的生化特性、生理功能和作用机制知之甚少。本文从蛋白结构、基因起源和生物学功能等方面简要介绍目前非晶状体βγ-晶状体蛋白的相关研究进展。
In vertebrates, βγ-crystallins are mainly expressed in the lens as structural protein, a lot of non-lens βγ-crystallins were also discovered in microbes and mammals, such as Protein S and Absent in Melanoma 1, which act as microbial stress-inducible protective protein in bacterial, participate in epidermis development and has tumor suppression function in mammals, respectively. However, little is known about the biochemical properties, functions and action mechanisms of these non-lens βγ--crystallins in vertebrates. In this paper, we mainly review the research progression of non-lensβγ-crystallins in the protein structure, gene evolution and biological function.
基金
国家自然基金(30630014
30570359)
中国科学院重要研究方向基金(KSCX2-YW-R-088)
