慢性肝炎转氨酶与肝组织形态定量的关系

The Relation Between the Elevation of Amiaotransferaes and Morphological Quantitative Analysis of the Liver Tissues in Chronic Hepatitis

本文对３４例临床和病理均诊为慢性肝炎的肝组织学切片，以点计数法测出良好肝细胞（ＧＯ）、变性肝细胞（ＤＥ）、小叶内炎症坏死（ＩＮ）、汇管区碎屑坏死（ＮＥ）、纤维化组织（ＦＩ）的面积，并计算其所占百分率。以活检前后３天所作肝功检查的ＡＬＴ、ＡＳＴ及ＡＳＴ／ＡＬＴ值与各组分面积百分率──进行二无相关回归分析。结果显示，ＡＬＴ与ＩＮ及肝总坏死面积呈显著正相关，与肝实质面积成显著负相关；ＡＳＴ则与ＮＥ及总炎症坏死面积呈非常显著正相关，与ＧＯ及肝实质面积成显著负相关；ＡＳＴ／ＡＬＴ值与ＮＥ及总炎症坏死面积成非常显著正相关。相关分析为慢性肝炎的治疗和预后判断提供了依据。

Abstract Purpose to understand the relation between the elevation of aminotransferases and morphologi- cal quantitative analysis of liver tissues in chronic hepatitis, Methods The point-counting morphometry of liver tissues from needle liver biopsy in 34 chronic hepatitis were studied by computerized interactive morphometry (CIM )system ,and the data between the aminotransferases and that from each of the variables measured were analyzed by the correlative analysis. Result : There was a correlation between ALT and the necrosis in small lobales , so was the total necrosis area (P<0. 05). There was a inverse correlation between ALT and the hep- aeic essense. AST was relate to both the piecemeal necrosis and the total necrosis area (P<0. 01 ) ,and AST was inverse relate to the hepatic essens; AST/ALT was relate to both the total necrosis and the pircemeal necrosis (P<0. 01 ). Conclusions:The study indicates that the morphological quantitative analysis in the liver tissues of chrotnic hepatitis might be significantly important to the analysis of treatment and prognosis.