血清Ⅳ型胶原在良恶性肝肿瘤鉴别中的价值

Evaluation of Serum Type ⅣCollagen in Differentiating Benign and Malignant Hepatic

对５８例肝癌、２９良性肝肿瘤、１３其他恶性肿瘤和３０名正常对照者例用一步夹心酶免疫法测定了血清Ⅳ型胶原（Ⅳ－Ｃ）水平。结果显示，肝癌组血清ＩＶ－Ｃ显著高于良性肝肿瘤、其它恶性肿瘤及正常对照组（Ｐ均＜０．００１）；血清ＩＶ－Ｃ对良、恶性肝肿瘤鉴别诊断的准确率为９０．８０％；对原发性肝癌（ＰＨＣ）的敏感性及特异性分别为９１．４８％和８９．６５％，敏感性优于血清ＡＦＰ，血清ＩＶ－Ｃ与ＡＦＰ联合测定对ＰＨＣ的敏感性及待异性分别为９５．７４％和８６．２０％。提示血清ＩＶ－Ｃ对良、恶性肝肿瘤的鉴别诊断具有一定价值。

Serum level of type IV collagen (IV - C ) were measured hy one step sandwich enzyme im- munoassay in 58 cases with hepatic carcinoma , 29 cases with benign hepatic tumor , 1 1 cases with other malig- nancy and 30 normal controls, Compared with controls , patients with benign hepatic tumor or other malignan- cy ,serum level of IV -C were significantly increased in patients with hepatic carcinoma (P<0. 001 ) , ThAe re sults suggested that serum IV-C may be an important marker in differntiating benign and malignant hepatic turmors.