应重视环境内分泌干扰物所致的儿童性发育异常

Environmental endocrine disruptors and abnormal sexual development in children

当前的正常儿童已较普遍地暴露于环境内分泌干扰物(EEDs)中,而EEDs与儿童性发育异常的发病有密切关系,是其重要的致病因素之一,应引起足够重视。尽快完善相关产业及环保方面的政策法规,从源头上杜绝这些有害物质造成的环境污染;另一方面应积极制定适合国情的有效防治方案,包括采用药物进行治疗干预。已证实恰当的中药治疗方案对EEDs的拟雌激素活性具有显著的拮抗作用。所用中药可通过对靶器官上雌激素受体、雌激素合成酶及生长因子的调节作用,发挥其对EEDs拟雌激素活性的拮抗作用。

Nowadays children are extensively exposed to the pollution of environmental endocrine disruptors （EEDs）, and it is well-known that there is a close relationship between EEDs and the onset of abnormal sexual development. This ought to attract sufficient attention of government, to improve the policies for related industries and for environmental protection as soon as possible, and put an end to the environmental pollution caused by these harmful materials. In addition, effective preventive and therapeutic interventions with medicines appropriate to our situation ought to be formulated. It has been verified that Chinese herbal medicine （CHM） could effectively counteract the estrogen-like activity of EEDs. This was achieved via regulative effects on estrogen receptors, estrogen synthetase, and growth factors in the target organs.