红细胞谷胱甘肽与恶性肿瘤化疗疗效的关系研究

Relationship between Erythrocyte Glutathione Concentration and Chemotherapeutic Effect on Malignant Tumors

检测１１６例恶性肿瘤患者化疗前后红细胞中的谷胱甘肽（ＧＳＨ）浓度，结果表明，除乳腺癌外，消化道肿瘤、恶性淋巴瘤、肺癌等肿瘤患者化疗前后红细胞ＧＳＨ明显增高，且与临床分期密切相关，所有肿瘤患者化疗前、后红细胞ＧＳＨ无明显差异，化疗无效患者化疗前红细胞ＧＳＨ明显高于化疗有效者。红细胞ＧＳＨ测定有助于恶性肿瘤患者化疗疗效。

Erythrocyte glutathione concentrations were determined in 116 cases of malignant tumor before and after chemotherapy. It was revealed that patients who had their malignant tumors irresponsive to chemotherapy usually showed significant increase of erythrocyte glutathione with fairly close association with clinical stage of the tumor. Determination of erythrocyte glutathione might serve as an indicator against chemotherapy in patients with malignant tumors.