乳腺癌患者的碱性谷胱甘肽S-转移酶

Alkaline Glutathione Stransferase in Patients with Breast Cancer

检测了３０例乳腺癌，２９例乳腺良性肿瘤和７５例健康女性血清ＧＳＴ－α含量，结果表明，乳腺癌患者血清中ＧＳＴ－α含量为０．７２±０．３１μｇ／Ｌ，阳性率为５６．７％，明显高于乳腺良性病变组（１７．２％）及健康对照组（４％），且患者手术前后血清ＧＳＴ－α水平差异显著（Ｐ＜０．０５）。但与乳癌患者的病理分期、组织类型、肿瘤大小及有无淋巴结转移等病理特征无关。

In this study,the serum level of GSTα was determined in 30 patients with breast cancers, 29 with benign breast tumors and 75 healthy subjects as control. The results showed that the level of GSTα in breast cancer patients was 0.72±0.31μg/L, with a positive rate of 56.7%. The positive rate of GSTα in breast cancer group was markedly higher than that in benign tumor group (17.2%) and the control group(4%).The difference of GSTα between the preoperative and postoperative values was significant (P<0.05). The GSTα level was not related to the pathological staging,histologic type,tumor size nor metastasis of lymph nodes in breast cancers.