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MicroRNA在乳腺癌中的研究进展 被引量：2

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摘要 MicroRNA(miRNA)是一类新发现的长度约22nt、广泛存在于动植物中、对基因的调控起着重要作用的单链非编码RNA。大量研究表明,miRNA通过调控细胞周期、细胞凋亡、细胞迁移和血管生成等肿瘤相关基因的表达,参与了肿瘤的发生、发展和预后。本文将主要讨论miRNA在乳腺癌中的研究进展。
作者 庞夏明 何超
机构地区 浙江大学医学院附属邵逸夫医院肛肠外科浙江省生物治疗重点实验室
出处 《实用肿瘤杂志》 CAS 2008年第6期570-573,共4页 Journal of Practical Oncology
关键词 乳腺肿瘤 微RNAS RNA 信使 综述
分类号 R737.9 [医药卫生—肿瘤]
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参考文献33

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同被引文献14

  • 1Loo TW, Clarke DM. Do drug substrates enter thecommon drug-binding pocket of P-glycoprotein through ”gates" [J]? Biochem Biophys Res Commun, 2005,329(2):419 -422.
  • 2Li Z, Hu S, Wang J, et al. MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in humanovarian cancer cells [ J]. Gynecol Oncol,2010,119( 1):125 -130.
  • 3Bai H, Xu R, Cao Z, et al. Involvement of miR-21 inresistance to daunorubicin by regulating PTEN expressionin the leukaemia K562 cell line [ J ]. FEBS Lett,2011,585(2) :402 -408.
  • 4Dong J, Zhao YP, Zhou L,et al. Bel-2 upregulationinduced by miR-21 via a direct interaction is associatedwith apoptosis and chemoresistance in MIA PaCa-2pancreatic cancer cells [J]. Arch Med Res,2011 , 42(1):8-14.'.
  • 5Shi L, Cheng Z, Zhang J, et al. hsa-mir-181 a and hsa-mir-181b function as tumor suppressors in human gliomacells [J]. Brain Res, 2008,1236: 185 - 193.
  • 6Fanini F,Vannini I, Fabbri M. MicroRNAs: tiny playerswith a big role in the pathogenesis of leukemias andlymphomas [ J]. Hematol Rev,2009,1(1) :40 -45.
  • 7Galluzzi L, Morselli E, Vitale L, et al. miR-181a andmiR-630 regulate cisplatin-induced cancer cell death[J]. Cancer Res, 2010,70(5) :1793 - 1803.
  • 8Zhu W, Shan X, Wang T,et al. miR-181b modulatesmultidrug resistance by targeting Bcl2 in human cancercell lines [ J]. Int J Cancer, 2010,127 ( 11 ) : 2520 -2529.
  • 9Chen G,Zhu W, Shi D, et al. MicroRNA-181 asensitizes human malignant glioma U87MG cells toradiation by targeting Bcl-2 [ J]. Oncol Rep, 2010,23(4):997 -1003.
  • 10Shuomin Zhu,Hailong Wu,Fangting Wu,Daotai Nie,Shijie Sheng,Yin-Yuan Mo.MicroRNA-21 targets tumor suppressor genes in invasion and metastasis[J].Cell Research,2008,18(3):350-359. 被引量：208

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实用肿瘤杂志
2008年 第6期

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