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理想的促性腺激素(剂量)刺激 被引量:4

Optimal Gn dose in COS
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摘要 Gn dose in controlled ovarian stimulation should be individual.To most normal responders,they maybe respond well to 150-200 IU/day in their first IVF cycle;to poor responders,although not supported by good evidence most authors seem to be comfortable with a starting dose of 300 IU/day and a maximum dose of 450 IU/day;to PCO or PCOS patients,most authors suggested a starting dose of 37.5-75 IU/day and a low dose step-up regimen. Gn dose in controlled ovarian stimulation should be individual. To most normal responders, they maybe respond well to 150-200 IU/day in their first IVF cycle; to poor responders, although not supported by good evidence most authors seem to be comfortable with a starting dose of 300 IU/day and a maximum dose of 450 IU/day; to PCO or PCOS patients, most authors suggested a starting dose of 37.5-75 IU/day and a low dose step-up regimen.
出处 《生殖医学杂志》 CAS 2008年第6期417-418,共2页 Journal of Reproductive Medicine
关键词 卵巢刺激 卵巢反应 促性腺激素剂量 Controlled ovarian stimulation Ovarian respond Gonadotrophin dose
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参考文献7

  • 1Rombauts L. Is there a recommended maximum starting dose of FSH in IVF? [J].J Assist Reprod Genet, 2007, 24(8): 343-349.
  • 2Cai J, Lou HY, Minyue Dong,et al. Poor ovarian response to gonadotropin stimulation is associated with low expression of follicle-stimulating hormone receptor in granulosa cells[J]. Fertil Steril, 2007, 87(6): 1350-1356.
  • 3Klinkert ER, Broekmans FJ, Looman CW, et al. Expected poor responders on the basis of an antral follicle count do not benefit from a higher starting dose of gonadotrophins in IVF treatment: a randomized controlled trial[J]. Hum Reprod, 2005,20(3) : 611-615.
  • 4Chen C, Kattera S. Beneficial effects of a higher starting dose of gonadotrophins in some poor responders[J]. Int Surg, 2006, 91[5 Suppl]:S31-36.
  • 5Nyboe Andersen A, Humaidan P, Fried G, et al. Addition of rLH (Luveris) to rFSH during the final days of follicular maturation in IVF/ICSI treated patients. A Nordic randomized multicenter trial[J]. Hum Reprod, 2006,21[Suppl 1]:O-138.
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  • 7van Santbrink E, Fauser B. Urinary follicle stimulating hor mone for normogonadotrophic clomiphene-resistant infertility: Prospective, randomized comparison between low dose step-up and step-down dose regimens[J]. J Clin Endocrinol Metab, 1997,82(11) : 3597-3602.

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